Standard Name	PSP2
Systematic Name	YML017W
Alias	MRS15
Feature Type	ORF, Verified
Description	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing (1, 2)
Name Description	Polymerase SuPpressor 2

Chromosomal Location	ChrXIII:236588 to 238731 | ORF Map | GBrowse

	View Computational GO annotations for PSP2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	lithium(1+) accumulation: decreased ionic stress resistance: increased
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased haploinsufficient resistance to fluconazole: decreased resistance to camptothecin: decreased resistance to fenpropimorph: increased resistance to caffeine: increased resistance to sirolimus: increased resistance to cycloheximide: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to wortmannin: normal resistance to bleomycin: increased resistance to calcium dichloride: decreased resistance to glycolaldehyde: decreased sporulation: normal stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	67 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 2 PCA: 2
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 33 Positive Genetic: 5 Synthetic Growth Defect: 9 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:236588 to 238731 | ORF Map | GBrowse
Last Update	Coordinates: 2004-01-30 | Sequence: 2004-01-30
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4 236588..236591 2004-01-30 2004-01-30 Intron 5..366 236592..236953 2004-01-30 2004-01-30 CDS 367..2144 236954..238731 2004-01-30 2004-01-30
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (5 - 366)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004479