TUS1/YLR425W Summary Help

TUS1 BASIC INFORMATION

Standard Name TUS1 1
Systematic Name YLR425W
Alias SOP10
Feature Type ORF, Verified
Description Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate (1, 2, 3)
Name Description TOR Unique function Suppressor 1
GO Annotations All TUS1 GO evidence and references
    View Computational GO annotations for TUS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All TUS1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions TUS1 All interactions details and references
43 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 4
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 14
  • Synthetic Rescue: 3
Sequence Information
ChrXII:982891 to 986814 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-09 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3924 982891..986814 2006-01-09 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004417

TUS1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TUS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TUS1]

1) Schmelzle T, et al.  (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39
2) Helliwell SB, et al.  (1998) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148(1):99-112
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64