YLR422W Summary

YLR422W Summary

Reserved Name	DCK1 1 This name is reserved with SGD according to the Gene Naming Guidelines agreed upon by the yeast community. For more information about this reservation, please see the Locus History.
Systematic Name	YLR422W
Feature Type	ORF, Uncharacterized
Description	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein (2, 3, 4)
Name Description	DOCK1 homolog 1

Chromosomal Location	ChrXII:965897 to 971695 \| ORF Map \| GBrowse

Gene Ontology Annotations All YLR422W GO evidence and references

	View Computational GO annotations for YLR422W
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
High-throughput	cytoplasm (IDA)

Mutant phenotypes All YLR422W Phenotype evidence and references

Large-scale survey
null	cell size: increased competitive fitness: increased endocytosis: decreased replicative lifespan: increased vacuolar morphology: abnormal viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All YLR422W Interaction evidence and references

	30 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 19 Positive Genetic: 1 Synthetic Growth Defect: 3
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DIP \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All YLR422W Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP \| YeastRC
Homologs	Ashbya (AGD) \| CGD Homologs \| CandidaDB Homologs \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXII:965897 to 971695 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..5799	965897..971695	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000004414

References cited on this page View Complete Literature Guide for

1)	Jendretzki A, et al. (2012) The Saccharomyces cerevisiae homologue of the DOCK/ELMO complex is a putative GEF for the small GTPase Rho5 ()
2)	Robinson KA, et al. (2000) A network of yeast basic helix-loop-helix interactions. Nucleic Acids Res 28(22):4460-6
3)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
4)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91