Standard Name	SMC6
Systematic Name	YLR383W
Alias	RHC18 1
Feature Type	ORF, Verified
Description	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18 (2, 3, 4)
Name Description	Structural Maintenance of Chromosomes

Chromosomal Location	ChrXII:885288 to 888632 | ORF Map | GBrowse

	View Computational GO annotations for SMC6
Molecular Function
Manually curated	damaged DNA binding (IDA)
Biological Process
Manually curated	chromosome separation (IMP) DNA repair (IDA, IMP) double-strand break repair via homologous recombination (IMP) resolution of recombination intermediates (IMP)
Cellular Component
Manually curated	nucleus (IDA) site of double-strand break (IDA) Smc5-Smc6 complex (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	UV resistance: decreased cell cycle progression: arrested cell cycle progression in anaphase: delayed chromosome segregation: abnormal chromosome segregation: delayed heat sensitivity: increased mitotic recombination: decreased rate mutation frequency: increased Rad53p modification: increased resistance to mitomycin C: decreased resistance to cisplatin: decreased resistance to camptothecin: decreased resistance to phleomycin: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal resistance to benomyl: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	104 total interaction(s) for 81 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-Western: 4 Co-purification: 1 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 40 Phenotypic Enhancement: 22 Phenotypic Suppression: 5 Synthetic Growth Defect: 9 Synthetic Lethality: 4 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:885288 to 888632 | ORF Map | GBrowse
Last Update	Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3345 885288..888632 2004-02-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004375