Standard Name	ILV5
Systematic Name	YLR355C
Feature Type	ORF, Verified
Description	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids (1, 2, 3, 4)
Name Description	IsoLeucine-plus-Valine requiring

Chromosomal Location	ChrXII:839253 to 838066 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 252 cM

	View Computational GO annotations for ILV5
Molecular Function
Manually curated	double-stranded DNA binding (IDA) ketol-acid reductoisomerase activity (IMP)
Biological Process
Manually curated	branched-chain amino acid biosynthetic process (IMP) mitochondrial genome maintenance (IGI, IMP)
Cellular Component
Manually curated	mitochondrial nucleoid (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	isoleucine biosynthesis superpathway of leucine, isoleucine, and valine biosynthesis valine biosynthesis

Classical genetics
null	mitochondrial genome maintenance: decreased petite
reduction of function	auxotrophy mitochondrial genome maintenance: decreased mitochondrial genome maintenance: normal petite
Large-scale survey
null	haploinsufficient inviable
reduction of function	competitive fitness: decreased telomere length: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	44 total interaction(s) for 38 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-RNA: 6 Co-fractionation: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 1 Phenotypic Suppression: 4 Synthetic Lethality: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:839253 to 838066 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 252 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1188 839253..838066 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004347