Standard Name	KAP95 1
Systematic Name	YLR347C
Alias	RSL1
Feature Type	ORF, Verified
Description	Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p (1, 2, 3, 4, 5)
Name Description	KAryoPherin 1

Chromosomal Location	ChrXII:826413 to 823828 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for KAP95
Molecular Function
Manually curated	protein transporter activity (IDA) Ran guanyl-nucleotide exchange factor activity (IDA)
Biological Process
Manually curated	nuclear pore complex assembly (IMP) phosphatidylcholine biosynthetic process (IGI, IMP) protein import into nucleus (IMP) protein targeting to membrane (IMP) regulation of protein desumoylation (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) colocalizes_with nuclear exosome (RNase complex) (IDA) nuclear pore (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	nuclear import: decreased nuclear transport: abnormal
repressible	cell cycle progression through the G2/M phase transition: arrested
unspecified	actin cytoskeleton morphology: abnormal endocytosis: decreased
Large-scale survey
null	haploproficient inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	292 total interaction(s) for 134 unique genes/features.
Physical Interactions	Affinity Capture-MS: 145 Affinity Capture-RNA: 1 Affinity Capture-Western: 49 Co-crystal Structure: 2 Co-fractionation: 1 Co-purification: 3 PCA: 6 Protein-peptide: 2 Protein-RNA: 1 Reconstituted Complex: 46 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 2 Negative Genetic: 8 Phenotypic Enhancement: 1 Positive Genetic: 7 Synthetic Growth Defect: 3 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:826413 to 823828 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature contains embedded feature(s): YLR347W-A
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2586 826413..823828 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004339