SPH1/YLR313C Summary Help

Standard Name SPH1 1
Systematic Name YLR313C
Alias YLR312C-B 2
Feature Type ORF, Verified
Description Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication (1, 2, 3)
Name Description SPa2 Homolog 1
Chromosomal Location
ChrXII:762342 to 760750 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SPH1 GO evidence and references
  View Computational GO annotations for SPH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
unspecified
Resources
28 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 14
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 530
Molecular Weight (Da) 59,006
Isoelectric Point (pI) 9.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:762342 to 760750 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YLR312C-B
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1593 762342..760750 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004305
References cited on this page View Complete Literature Guide for SPH1
1) Arkowitz RA and Lowe N  (1997) A small conserved domain in the yeast Spa2p is necessary and sufficient for its polarized localization. J Cell Biol 138(1):17-36
2) Roemer T, et al.  (1998) The Spa2-related protein, Sph1p, is important for polarized growth in yeast. J Cell Sci 111 ( Pt 4)():479-94
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61