Standard Name	ARV1 1
Systematic Name	YLR242C
Feature Type	ORF, Verified
Description	Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p (1, 2, 3, 4)
Name Description	ARE2 Required for Viability 1

Chromosomal Location	ChrXII:623883 to 622918 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ARV1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	endocytosis (IMP) ER to Golgi ceramide transport (IMP) GPI anchor biosynthetic process (IMP) intracellular sterol transport (IMP) sphingolipid biosynthetic process (IMP) sterol import (IGI, IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) Golgi apparatus (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	ergosterol accumulation: increased endocytosis: decreased heat sensitivity: increased mating efficiency: decreased Ste5-GFP distribution: abnormal Gas1p modification: decreased resistance to nystatin: decreased vacuolar morphology: abnormal
Large-scale survey
null	alkaline pH resistance: decreased auxotrophy glycogen accumulation: increased competitive fitness: decreased competitive fitness: increased dessication resistance: decreased fermentative growth: decreased rate protein transport: abnormal resistance to sirolimus: decreased resistance to fenpropimorph: increased resistance to nickel sulfate: increased resistance to cycloheximide: decreased resistance to miconazole: decreased resistance to amiodarone: decreased resistance to fluconazole: decreased resistance to quinine: decreased resistance to hygromycin B: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to chloroquine: decreased resistance to mefloquine: decreased resistance to wortmannin: normal resistance to lovastatin: decreased resistance to spermine: decreased resistance to L-1,4-dithiothreitol: decreased resistance to sorbate: decreased telomere length: decreased transposable element transposition: decreased vacuolar morphology: abnormal vegetative growth: decreased rate vegetative growth: absent viable
overexpression	resistance to sirolimus: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	386 total interaction(s) for 239 unique genes/features.
Physical Interactions	Biochemical Activity: 3 PCA: 4 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 5 Negative Genetic: 243 Phenotypic Enhancement: 2 Phenotypic Suppression: 7 Positive Genetic: 103 Synthetic Growth Defect: 10 Synthetic Lethality: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:623883 to 622918 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..966 623883..622918 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004232