ARV1/YLR242C Summary Help

Standard Name ARV1 1
Systematic Name YLR242C
Feature Type ORF, Verified
Description Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p (1, 2, 3, 4, 5)
Name Description ARE2 Required for Viability 1
Chromosomal Location
ChrXII:623883 to 622918 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ARV1 GO evidence and references
  View Computational GO annotations for ARV1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
466 total interaction(s) for 271 unique genes/features.
Physical Interactions
  • Biochemical Activity: 3
  • PCA: 4
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 311
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 7
  • Positive Genetic: 115
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 321
Molecular Weight (Da) 38,194
Isoelectric Point (pI) 9.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:623883 to 622918 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..966 623883..622918 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004232
References cited on this page View Complete Literature Guide for ARV1
1) Tinkelenberg AH, et al.  (2000) Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem 275(52):40667-70
2) Swain E, et al.  (2002) Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem 277(39):36152-60
3) Kajiwara K, et al.  (2008) Yeast ARV1 Is Required for Efficient Delivery of an Early GPI Intermediate to the First Mannosyltransferase during GPI Assembly and Controls Lipid Flow from the Endoplasmic Reticulum. Mol Biol Cell 19(5):2069-82
4) Tong F, et al.  (2010) Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. J Biol Chem 285(44):33632-41
5) Georgiev AG, et al.  (2013) Arv1 Regulates PM and ER Membrane Structure and Homeostasis But is Dispensable for Intracellular Sterol Transport. Traffic 14(8):912-21