MSC3/YLR219W Summary Help

Standard Name MSC3 1
Systematic Name YLR219W
Feature Type ORF, Verified
Description Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Meiotic Sister-Chromatid recombination 1
Chromosomal Location
ChrXII:574151 to 576337 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MSC3 GO evidence and references
  View Computational GO annotations for MSC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Large-scale survey
null
overexpression
Resources
31 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 5
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 12
  • Positive Genetic: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 728
Molecular Weight (Da) 80,530
Isoelectric Point (pI) 9.97
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:574151 to 576337 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2187 574151..576337 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004209
References cited on this page View Complete Literature Guide for MSC3
1) Thompson DA and Stahl FW  (1999) Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Genetics 153(2):621-41
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76