ATG38/YLR211C Summary Help

Standard Name ATG38 1
Systematic Name YLR211C
Feature Type ORF, Verified
Description Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy (1, 2, 3)
Name Description AuTophaGy related 4
Chromosomal Location
ChrXII:564531 to 563792 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ATG38 GO evidence and references
  View Computational GO annotations for ATG38
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
8 total interaction(s) for 7 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 3
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 226
Molecular Weight (Da) 25,975
Isoelectric Point (pI) 5.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:564531 to 563792 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-07-14
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..18 564531..564514 2011-02-03 2000-07-14
Intron 19..77 564513..564455 2011-02-03 2000-07-14
CDS 78..740 564454..563792 2011-02-03 2000-07-14
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004201
References cited on this page View Complete Literature Guide for ATG38
1) Araki Y, et al.  (2013) Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol 203(2):299-313
2) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Klionsky DJ, et al.  (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45