HMX1/YLR205C Summary Help

Standard Name HMX1 1
Systematic Name YLR205C
Feature Type ORF, Verified
Description ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants (2, 3, 4, 5, 6)
Name Description HeMe oXygenase 3
Chromosomal Location
ChrXII:553677 to 552724 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HMX1 GO evidence and references
  View Computational GO annotations for HMX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
16 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 9
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 317
Molecular Weight (Da) 37,179
Isoelectric Point (pI) 7.97
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:553677 to 552724 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-02-05
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..954 553677..552724 2011-02-03 2004-02-05
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004195
References cited on this page View Complete Literature Guide for HMX1
1) Reggiori F and Pelham HR  (2001) Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J 20(18):5176-86
2) Foury F and Talibi D  (2001) Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. J Biol Chem 276(11):7762-8
3) Auclair K, et al.  (2003) Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif 28(2):340-9
4) Protchenko O and Philpott CC  (2003) Regulation of intracellular heme levels by HMX1, a homologue of heme oxygenase, in Saccharomyces cerevisiae. J Biol Chem 278(38):36582-7
5) Kim D, et al.  (2006) Fungal heme oxygenases: Functional expression and characterization of Hmx1 from Saccharomyces cerevisiae and CaHmx1 from Candida albicans. Biochemistry 45(49):14772-80
6) Collinson EJ, et al.  (2011) The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes. J Biol Chem 286(3):2205-14