SWI6/YLR182W Summary Help

SWI6 BASIC INFORMATION

Standard Name SWI6
Systematic Name YLR182W
Alias PSL8 , SDS11 1
Feature Type ORF, Verified
Description Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate (2, 3, 4, 5)
Name Description SWItching deficient
GO Annotations All SWI6 GO evidence and references
    View Computational GO annotations for SWI6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs SWI6 Transcription Factor Binding Sites and References
  • CACGAAAA
  • CGCGAAA
Mutant Phenotype All SWI6 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions SWI6 All interactions details and references
318 total interaction(s) for 222 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 17
  • Biochemical Activity: 9
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 9
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Rescue: 13
  • Phenotypic Enhancement: 93
  • Phenotypic Suppression: 41
  • Synthetic Growth Defect: 47
  • Synthetic Lethality: 50
  • Synthetic Rescue: 9
Sequence Information
ChrXII:517942 to 520353 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2412 517942..520353 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004172

SWI6 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SWI6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SWI6]

1) Sussel L, et al.  (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88
2) Leem SH, et al.  (1998) Meiotic role of SWI6 in Saccharomyces cerevisiae. Nucleic Acids Res 26(13):3154-8
3) Sidorova JM, et al.  (1995) Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization. Mol Biol Cell 6(12):1641-58
4) Horak CE, et al.  (2002) Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Genes Dev 16(23):3017-33
5) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64