SEC10/YLR166C Summary Help

Standard Name SEC10 1
Systematic Name YLR166C
Feature Type ORF, Verified
Description Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion (2, 3, 4)
Name Description SECretory 5
Chromosomal Location
ChrXII:498044 to 495429 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SEC10 GO evidence and references
  View Computational GO annotations for SEC10
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
Large-scale survey
null
reduction of function
repressible
Resources
214 total interaction(s) for 109 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 86
  • Affinity Capture-Western: 20
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 1
  • Reconstituted Complex: 8
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 8
  • Dosage Rescue: 10
  • Negative Genetic: 22
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 32
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 871
Molecular Weight (Da) 100,341
Isoelectric Point (pI) 6.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:498044 to 495429 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2616 498044..495429 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004156
References cited on this page View Complete Literature Guide for SEC10
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Finger FP and Novick P  (1998) Spatial regulation of exocytosis: lessons from yeast. J Cell Biol 142(3):609-12
3) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
4) TerBush DR and Novick P  (1995) Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol 130(2):299-312
5) Novick P and Schekman R  (1979) Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 76(4):1858-62