STM1/YLR150W Summary Help

Standard Name STM1 1
Systematic Name YLR150W
Alias MPT4 2
Feature Type ORF, Verified
Description Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery (1, 3, 4, 5, 6, 7, 8, 9)
Name Description Suppressor of ToM1 1
Chromosomal Location
ChrXII:440467 to 441288 | ORF Map | GBrowse
Gene Ontology Annotations All STM1 GO evidence and references
  View Computational GO annotations for STM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 136 genes
Classical genetics
Large-scale survey
249 total interaction(s) for 222 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 143
  • Affinity Capture-RNA: 7
  • Affinity Capture-Western: 1
  • Biochemical Activity: 5
  • PCA: 3
  • Protein-peptide: 7
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 4
  • Dosage Lethality: 3
  • Dosage Rescue: 18
  • Negative Genetic: 39
  • Positive Genetic: 9
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 273
Molecular Weight (Da) 29,995
Isoelectric Point (pI) 10.45
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXII:440467 to 441288 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..822 440467..441288 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004140
References cited on this page View Complete Literature Guide for STM1
1) Utsugi T, et al.  (1995) A high dose of the STM1 gene suppresses the temperature sensitivity of the tom1 and htr1 mutants in Saccharomyces cerevisiae. Biochim Biophys Acta 1263(3):285-8
2) Frantz JD and Gilbert W  (1995) A yeast gene product, G4p2, with a specific affinity for quadruplex nucleic acids. J Biol Chem 270(16):9413-9
3) Nelson LD, et al.  (2000) The yeast STM1 gene encodes a purine motif triple helical DNA-binding protein. J Biol Chem 275(8):5573-81
4) Hayashi N and Murakami S  (2002) STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiae. Mol Genet Genomics 267(6):806-13
5) Van Dyke MW, et al.  (2004) Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. J Biol Chem 279(23):24323-33
6) Van Dyke N, et al.  (2006) Stm1p, a ribosome-associated protein, is important for protein synthesis in Saccharomyces cerevisiae under nutritional stress conditions. J Mol Biol 358(4):1023-31
7) Van Dyke N, et al.  (2009) Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation. Nucleic Acids Res 37(18):6116-25
8) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
9) Van Dyke N, et al.  (2013) The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence. Biochem Biophys Res Commun 430(2):745-50