STM1/YLR150W Summary 
| Standard Name | STM1 1 (see Nomenclature conflict Note) |
|---|---|
| Systematic Name | YLR150W |
| Alias | MPT4 2 |
| Feature Type | ORF, Verified |
| Description | Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery (1, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | Suppressor of tom1 1 |
| Chromosomal Location | |
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Gene Ontology Annotations All STM1 GO evidence and references
| View Computational GO annotations for STM1 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All STM1 Phenotype evidence and references
interactions All STM1 Interaction evidence and references
| 243 total interaction(s) for 218 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All STM1 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004140 |
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NOMENCLATURE CONFLICT NOTE
| Name | Relevance | Description |
|---|---|---|
| TIF3 | Nomenclature conflict | Both YPR163C/TIF3 and YLR150W/STM1 have been referred to as STM1. |
References cited on this page View Complete Literature Guide for STM1
| 1) | Utsugi T, et al. (1995) A high dose of the STM1 gene suppresses the temperature sensitivity of the tom1 and htr1 mutants in Saccharomyces cerevisiae. Biochim Biophys Acta 1263(3):285-8 |
| 2) | Frantz JD and Gilbert W (1995) A yeast gene product, G4p2, with a specific affinity for quadruplex nucleic acids. J Biol Chem 270(16):9413-9 |
| 3) | Nelson LD, et al. (2000) The yeast STM1 gene encodes a purine motif triple helical DNA-binding protein. J Biol Chem 275(8):5573-81 |
| 4) | Hayashi N and Murakami S (2002) STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiae. Mol Genet Genomics 267(6):806-13 |
| 5) | Van Dyke MW, et al. (2004) Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. J Biol Chem 279(23):24323-33 |
| 6) | Van Dyke N, et al. (2006) Stm1p, a ribosome-associated protein, is important for protein synthesis in Saccharomyces cerevisiae under nutritional stress conditions. J Mol Biol 358(4):1023-31 |
| 7) | Van Dyke N, et al. (2009) Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation. Nucleic Acids Res 37(18):6116-25 |
| 8) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 9) | Van Dyke N, et al. (2013) The Saccharomyces cerevisiae protein Stm1p facilitates ribosome preservation during quiescence. Biochem Biophys Res Commun 430(2):745-50 |
