Standard Name	SLX4
Systematic Name	YLR135W
Feature Type	ORF, Verified
Description	Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress (1, 2, 3, 4)
Name Description	Synthetic Lethal of unknown (X) function 5

Chromosomal Location	ChrXII:413281 to 415527 | ORF Map | GBrowse

	View Computational GO annotations for SLX4
Molecular Function
Manually curated	5'-flap endonuclease activity (IDA)
Biological Process
Manually curated	DNA replication (IMP) DNA-dependent DNA replication (IGI) double-strand break repair via single-strand annealing, removal of nonhomologous ends (IGI, IMP) interstrand cross-link repair (IGI) response to DNA damage stimulus (IGI)
Cellular Component
Manually curated	nucleus (IC, IMP) Slx1-Slx4 complex (IPI)
High-throughput	nucleus (IDA)

Classical genetics
null	mitotic recombination: decreased mutation frequency: increased resistance to methyl methanesulfonate: decreased
Large-scale survey
null	competitive fitness: increased resistance to cisplatin: decreased resistance to bleomycin: increased resistance to tunicamycin: increased resistance to methyl methanesulfonate: decreased resistance to sodium selenide: decreased resistance to hydroxyurea: decreased resistance to camptothecin: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: increased vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	148 total interaction(s) for 90 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-Western: 11 Co-purification: 1 Reconstituted Complex: 3 Two-hybrid: 8
Genetic Interactions	Dosage Growth Defect: 3 Negative Genetic: 39 Phenotypic Enhancement: 6 Phenotypic Suppression: 3 Positive Genetic: 4 Synthetic Growth Defect: 33 Synthetic Lethality: 19 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:413281 to 415527 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2247 413281..415527 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004125