Standard Name	APC9 1
Systematic Name	YLR102C
Feature Type	ORF, Verified
Description	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition (1, 2)
Name Description	Anaphase Promoting Complex 1

Chromosomal Location	ChrXII:343767 to 342970 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for APC9
Molecular Function
Manually curated	contributes_to ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	chromatin assembly (IGI) protein ubiquitination (IMP)
Cellular Component
Manually curated	anaphase-promoting complex (IDA)

Regulatory modules	predicted: stressResponse (529)

Classical genetics
null	cell cycle passage through the metaphase-anaphase transition: delayed vegetative growth: decreased rate
Large-scale survey
null	competitive fitness: increased haploproficient resistance to camptothecin: decreased resistance to bleomycin: increased resistance to caffeine: increased resistance to fenpropimorph: increased resistance to sirolimus: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	117 total interaction(s) for 59 unique genes/features.
Physical Interactions	Affinity Capture-MS: 33 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 7 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 3 Negative Genetic: 36 Positive Genetic: 12 Synthetic Growth Defect: 5 Synthetic Lethality: 8 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:343767 to 342970 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..798 343767..342970 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004092