Standard Name	CHA4 1
Systematic Name	YLR098C
Alias	SIL2 2 , SIL3 2
Feature Type	ORF, Verified
Description	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain (1, 3)
Name Description	Catabolism of Hydroxy Amino acids 1, 4

Chromosomal Location	ChrXII:339473 to 337527 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CHA4
Molecular Function
Manually curated	sequence-specific DNA binding transcription factor activity (IDA, IPI, ISS)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular amino acid catabolic process (IGI, IMP) positive regulation of transcription, DNA-dependent (IMP)
Cellular Component
Manually curated	nucleus (IPI)

Binding motifs	ANNTCCGCC 5 [Search intergenic regions for ANNTCCGCC] WCYCCGCY 6 [Search intergenic regions for WCYCCGCY]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	resistance to tellurite: decreased
Large-scale survey
null	competitive fitness: increased haploproficient resistance to neomycin: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	78 total interaction(s) for 74 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 5 Two-hybrid: 16
Genetic Interactions	Negative Genetic: 41 Phenotypic Enhancement: 2 Positive Genetic: 10 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:339473 to 337527 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1947 339473..337527 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004088