SMC4/YLR086W Summary Help

SMC4 BASIC INFORMATION

Standard Name SMC4
Systematic Name YLR086W
Feature Type ORF, Verified
Description Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate (1, 2, 3 and see Summary Paragraph)
Name Description Structural Maintenance of Chromosomes
GO Annotations All SMC4 GO evidence and references
    View Computational GO annotations for SMC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SMC4 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
repressible
Interactions SMC4 All interactions details and references
27 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 7
Genetic Interactions
  • Phenotypic Enhancement: 1
Sequence Information
ChrXII:302244 to 306500 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4257 302244..306500 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004076

SMC4 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SMC4

SUMMARY PARAGRAPH for SMC4

SMC4 is an essential gene that encodes a member of a ubiquitous family of chromosome-associated ATPases (4, 5, 6). SMC proteins are found in eukaryotes, prokaryotes, and archaea, and appear to play roles in chromosome dynamics (5, 6). In eukaryotes, SMC proteins form two kinds of heterodimers, corresponding to Smc1p-Smc3p and Smc2p-Smc4p in yeast (5, 6). The Smc2p-Smc4p heterodimer interacts with additional proteins, Brn1p, Ycg1p, and Loc7p, to form the yeast condensin complex(6, 5, 7, 8). Originally identified in Xenopus egg extracts, the condensin complex is required for chromosome condensation (9, 6, 5). Condensin complexes have been identified in many eukaryotes, including Drosophila, human, and S. pombe (5).

Last updated: 2000-05-04

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SMC4]

1) Stray JE and Lindsley JE  (2003) Biochemical analysis of the yeast condensin Smc2/4 complex: an ATPase that promotes knotting of circular DNA. J Biol Chem 278(28):26238-48
2) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
3) Haeusler RA, et al.  (2008) Clustering of yeast tRNA genes is mediated by specific association of condensin with tRNA gene transcription complexes. Genes Dev 22(16):2204-14
4) Koshland D and Strunnikov A  (1996) Mitotic chromosome condensation. Annu Rev Cell Dev Biol 12:305-33
5) Hirano T  (1999) SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes Dev 13(1):11-9
6) Strunnikov AV and Jessberger R  (1999) Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Eur J Biochem 263(1):6-13
7) Ouspenski II, et al.  (2000) Chromosome condensation factor Brn1p is required for chromatid separation in mitosis. Mol Biol Cell 11(4):1305-13
8) Lavoie BD, et al.  (2000) Mitotic chromosome condensation requires Brn1p, the yeast homologue of Barren. Mol Biol Cell 11(4):1293-304
9) Hirano T, et al.  (1997) Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Cell 89(4):511-21