EMP70/YLR083C Summary

EMP70 BASIC INFORMATION

Standard Name	EMP70 1
Systematic Name	YLR083C
Alias	TMN1 2
Feature Type	ORF, Verified
Description	Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions (1, 2) Also known as: p24a 3

GO Annotations	All EMP70 GO evidence and references
	View Computational GO annotations for EMP70
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	invasive growth in response to glucose limitation (IMP) pseudohyphal growth (IGI)
Cellular Component
Manually curated	endosome (IDA)

Mutant Phenotype	All EMP70 Phenotype details and references
Classical genetics
null	invasive growth: decreased
Large-scale survey
null	UV resistance: decreased respiratory growth: decreased rate sporulation: decreased viable

Interactions	EMP70 All interactions details and references
	33 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 PCA: 4 Two-hybrid: 20
Genetic Interactions	Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 2

Sequence Information

ChrXII:296095 to 294092 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2004	296095..294092	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004073

EMP70 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for EMP70

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EMP70]

1)	Schimmoller F, et al. (1998) Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution. Gene 216(2):311-8
2)	Froquet R, et al. (2008) Control of Cellular Physiology by TM9 Proteins in Yeast and Dictyostelium. J Biol Chem 283(11):6764-6772
3)	Singer-Kruger B, et al. (1993) Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins. J Biol Chem 268(19):14376-86

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