NSE1/YLR007W Summary Help

Standard Name NSE1 1
Systematic Name YLR007W
Feature Type ORF, Verified
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair (1, 2, 3, 4)
Name Description Non-SMC Element 1
Chromosomal Location
ChrXII:164392 to 165402 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NSE1 GO evidence and references
  View Computational GO annotations for NSE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
repressible
Large-scale survey
conditional
null
reduction of function
repressible
Resources
31 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Co-purification: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 8
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 336
Molecular Weight (Da) 38,334
Isoelectric Point (pI) 5.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:164392 to 165402 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1011 164392..165402 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003997
References cited on this page View Complete Literature Guide for NSE1
1) Fujioka Y, et al.  (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91
2) Zhao X and Blobel G  (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82
3) Dardalhon M, et al.  (2007) Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast. FEMS Yeast Res 7(6):866-878
4) Bermudez-Lopez M, et al.  (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12