Standard Name	SSL1
Systematic Name	YLR005W
Feature Type	ORF, Verified
Description	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p (1, 2, 3)
Name Description	Suppressor of Stem-Loop mutation 4

Chromosomal Location	ChrXII:160049 to 161434 | ORF Map | GBrowse

	View Computational GO annotations for SSL1
Molecular Function
Manually curated	contributes_to core RNA polymerase binding transcription factor activity (IC)
Biological Process
Manually curated	nucleotide-excision repair (IMP) phosphorylation of RNA polymerase II C-terminal domain (IDA) transcription from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	core TFIIH complex (IDA) holo TFIIH complex (IDA) nucleotide-excision repair factor 3 complex (IDA)

Classical genetics
conditional	UV resistance: decreased cold sensitivity: increased colony sectoring: increased heat sensitivity: increased vegetative growth: decreased rate
null	inviable
reduction of function	UV resistance: decreased resistance to methyl methanesulfonate: decreased
Large-scale survey
conditional	colony sectoring: increased heat sensitivity: increased
null	haploproficient inviable resistance to tenovin-6: decreased
overexpression	vegetative growth: decreased rate
reduction of function	colony sectoring: increased competitive fitness: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	131 total interaction(s) for 92 unique genes/features.
Physical Interactions	Affinity Capture-MS: 23 Affinity Capture-Western: 5 Biochemical Activity: 1 Co-crystal Structure: 1 Co-purification: 12 PCA: 1 Reconstituted Complex: 5
Genetic Interactions	Negative Genetic: 66 Phenotypic Suppression: 1 Positive Genetic: 6 Synthetic Growth Defect: 1 Synthetic Lethality: 4 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:160049 to 161434 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1386 160049..161434 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003995