Standard Name	NOC3
Systematic Name	YLR002C
Feature Type	ORF, Verified
Description	Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing (1, 2, 3)
Name Description	NucleOlar Complex associated 1

Chromosomal Location	ChrXII:156334 to 154343 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NOC3
Molecular Function
Manually curated	chromatin binding (IDA)
Biological Process
Manually curated	DNA replication initiation (IDA) pre-replicative complex assembly (IMP) rRNA processing (IDA)
Cellular Component
Manually curated	Noc2p-Noc3p complex (IPI) nucleolus (IDA) nucleoplasm (IDA) nucleus (IDA) pre-replicative complex (IDA)

Classical genetics
conditional	cell cycle progression through the G1/S phase transition: delayed chromosome/plasmid maintenance: decreased Mcm2p distribution: absent
null	dessication resistance: increased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable starvation resistance: decreased
overexpression	vegetative growth: decreased rate
reduction of function	colony sectoring: increased competitive fitness: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	170 total interaction(s) for 122 unique genes/features.
Physical Interactions	Affinity Capture-MS: 88 Affinity Capture-Western: 15 Co-fractionation: 2 PCA: 1 Two-hybrid: 13
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 5 Negative Genetic: 36 Positive Genetic: 2 Synthetic Growth Defect: 3 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:156334 to 154343 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1992 156334..154343 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003992