SPA2/YLL021W Summary Help

SPA2 BASIC INFORMATION

Standard Name SPA2 1
Systematic Name YLL021W
Alias FUS6 2 , PEA1 3
Feature Type ORF, Verified
Description Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate (4, 5, 6)
Name Description Spindle Pole Antigen 1
GO Annotations All SPA2 GO evidence and references
    View Computational GO annotations for SPA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SPA2 Phenotype details and references
Classical genetics
null
overexpression
reduction of function
unspecified
Large-scale survey
null
Interactions SPA2 All interactions details and references
113 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-Western: 5
  • Biochemical Activity: 2
  • Co-localization: 3
  • PCA: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 15
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 15
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 24
  • Synthetic Rescue: 4
Sequence Information
ChrXII:100946 to 105346 | ORF Map | GBrowse
Gbrowse
Genetic position: -28 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4401 100946..105346 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003944

SPA2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SPA2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPA2]

1) Snyder M  (1989) The SPA2 protein of yeast localizes to sites of cell growth. J Cell Biol 108(4):1419-29
2) Gammie AE, et al.  (1998) Distinct morphological phenotypes of cell fusion mutants. Mol Biol Cell 9(6):1395-410
3) Chenevert J, et al.  (1994) Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae. Genetics 136(4):1287-96
4) Sheu YJ, et al.  (1998) Spa2p interacts with cell polarity proteins and signaling components involved in yeast cell morphogenesis. Mol Cell Biol 18(7):4053-69
5) van Drogen F and Peter M  (2002) Spa2p functions as a scaffold-like protein to recruit the Mpk1p MAP kinase module to sites of polarized growth. Curr Biol 12(19):1698-703
6) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64