YLL017W Summary

YLL017W Summary

Systematic Name	YLL017W
Alias	SDC25 1
Feature Type	pseudogene
Description	Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication (1, 2, 3)

Chromosomal Location	ChrXII:112234 to 112545 \| ORF Map \| GBrowse

Gene Ontology Annotations All YLL017W GO evidence and references

	View Computational GO annotations for YLL017W
Molecular Function
Manually curated	Ras guanyl-nucleotide exchange factor activity (TAS)
Biological Process
Manually curated	Ras protein signal transduction (TAS)
Cellular Component
Manually curated	membrane (IDA)

Mutant phenotypes All YLL017W Phenotype evidence and references

Large-scale survey
null	competitive fitness: increased viable
Resources	PROPHECY \| SCMD

interactions All YLL017W Interaction evidence and references

	9 total interaction(s) for 7 unique genes/features.
Physical Interactions	Biochemical Activity: 2 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Positive Genetic: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID

Expression Summary


Resources	Genevestigator \| YMGV

Protein Information All YLL017W Protein evidence and references

Localization	YeastGFP
Phosphorylation	PhosphoGRID
Structure	SCOP \| YeastRC
Homologs	PDB Homologs

sequence information

ChrXII:112234 to 112545 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..312	112234..112545	2011-02-03	1996-07-31

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP vs. fungi \| Synteny Viewer

Resources

External Links	All Associated Seq \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000003940

References cited on this page View Complete Literature Guide for

1)	Damak F, et al. (1991) SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae. Mol Cell Biol 11(1):202-12
2)	Boy-Marcotte E, et al. (1996) SDC25, a dispensable Ras guanine nucleotide exchange factor of Saccharomyces cerevisiae differs from CDC25 by its regulation. Mol Biol Cell 7(4):529-39
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61