SDC25/YLL016W Summary Help

Standard Name SDC25 1
Systematic Name YLL016W
Feature Type pseudogene
Description Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Suppressor of cdc25
Chromosomal Location
ChrXII:112847 to 115993 | ORF Map | GBrowse
Genetic position: -3 cM
Gene Ontology Annotations All SDC25 GO evidence and references
  View Computational GO annotations for SDC25
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Large-scale survey
10 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Co-purification: 1
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Rescue: 1
  • Negative Genetic: 2
  • Phenotypic Enhancement: 1

Expression Summary
Length (a.a.) 1,048
Molecular Weight (Da) 121,960
Isoelectric Point (pI) 6.27
Phosphorylation PhosphoGRID
sequence information
ChrXII:112847 to 115993 | ORF Map | GBrowse
Genetic position: -3 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3147 112847..115993 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
External Links All Associated Seq | Search all NCBI (Entrez)
Primary SGDIDS000003939
References cited on this page View Complete Literature Guide for SDC25
1) Damak F, et al.  (1991) SDC25, a CDC25-like gene which contains a RAS-activating domain and is a dispensable gene of Saccharomyces cerevisiae. Mol Cell Biol 11(1):202-12
2) Boy-Marcotte E, et al.  (1996) SDC25, a dispensable Ras guanine nucleotide exchange factor of Saccharomyces cerevisiae differs from CDC25 by its regulation. Mol Biol Cell 7(4):529-39
3) Boy-Marcotte E, et al.  (1989) The C-terminal part of a gene partially homologous to CDC 25 gene suppresses the cdc25-5 mutation in Saccharomyces cerevisiae. Gene 77(1):21-30
4) Crechet JB, et al.  (2000) Analysis of the role of the hypervariable region of yeast Ras2p and its farnesylation in the interaction with exchange factors and adenylyl cyclase. J Biol Chem 275(23):17754-61
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61