MMM1/YLL006W Summary Help

Standard Name MMM1 1
Systematic Name YLL006W
Alias YME6 2
Feature Type ORF, Verified
Description ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase (1, 3, 4, 5, 6, 7, 8)
Name Description Maintenance of Mitochondrial Morphology 1
Chromosomal Location
ChrXII:136586 to 137866 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MMM1 GO evidence and references
  View Computational GO annotations for MMM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
conditional
null
Large-scale survey
null
overexpression
Resources
481 total interaction(s) for 387 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 35
  • Affinity Capture-Western: 16
  • PCA: 10

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 306
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 78
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 8
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 426
Molecular Weight (Da) 48,660
Isoelectric Point (pI) 5.45
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:136586 to 137866 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1281 136586..137866 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003929
References cited on this page View Complete Literature Guide for MMM1
1) Burgess SM, et al.  (1994) MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J Cell Biol 126(6):1375-91
2) Hanekamp T, et al.  (2002) Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Genetics 162(3):1147-56
3) Boldogh I, et al.  (1998) Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. J Cell Biol 141(6):1371-81
4) Hobbs AE, et al.  (2001) Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J Cell Biol 152(2):401-10
5) Meisinger C, et al.  (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J 26(9):2229-39
6) Kornmann B, et al.  (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81
7) Bockler S and Westermann B  (2014) Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast. Dev Cell 28(4):450-8
8) Cohen Y, et al.  (2014) Peroxisomes are juxtaposed to strategic sites on mitochondria. Mol Biosyst 10(7):1742-8