MMM1/YLL006W Summary Help

Standard Name MMM1 1
Systematic Name YLL006W
Alias YME6 2
Feature Type ORF, Verified
Description ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase (1, 3, 4, 5, 6, 7, 8)
Name Description Maintenance of Mitochondrial Morphology 1
Chromosomal Location
ChrXII:136586 to 137866 | ORF Map | GBrowse
Gene Ontology Annotations All MMM1 GO evidence and references
  View Computational GO annotations for MMM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
Large-scale survey
481 total interaction(s) for 387 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 35
  • Affinity Capture-Western: 16
  • PCA: 10

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 306
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 78
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 8
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 426
Molecular Weight (Da) 48,660
Isoelectric Point (pI) 5.45
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXII:136586 to 137866 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1281 136586..137866 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003929
References cited on this page View Complete Literature Guide for MMM1
1) Burgess SM, et al.  (1994) MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. J Cell Biol 126(6):1375-91
2) Hanekamp T, et al.  (2002) Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Genetics 162(3):1147-56
3) Boldogh I, et al.  (1998) Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. J Cell Biol 141(6):1371-81
4) Hobbs AE, et al.  (2001) Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J Cell Biol 152(2):401-10
5) Meisinger C, et al.  (2007) The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria. EMBO J 26(9):2229-39
6) Kornmann B, et al.  (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-81
7) Bockler S and Westermann B  (2014) Mitochondrial ER Contacts Are Crucial for Mitophagy in Yeast. Dev Cell 28(4):450-8
8) Cohen Y, et al.  (2014) Peroxisomes are juxtaposed to strategic sites on mitochondria. Mol Biosyst 10(7):1742-8