SFI1/YLL003W Summary

SFI1 BASIC INFORMATION

Standard Name	SFI1 1
Systematic Name	YLL003W
Feature Type	ORF, Verified
Description	Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C (1, 2)
Name Description	Suppressor of Fermentation Induced loss of stress resistance 1

GO Annotations	All SFI1 GO evidence and references
	View Computational GO annotations for SFI1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	G2/M transition of mitotic cell cycle (IMP) spindle assembly (IMP) spindle pole body duplication in nuclear envelope (IMP)
Cellular Component
Manually curated	half bridge of spindle pole body (IDA)

Mutant Phenotype	All SFI1 Phenotype details and references
Classical genetics
conditional	cell cycle progression: arrested heat sensitivity: increased
null	viable
overexpression	thermotolerance: decreased
repressible	cell cycle progression in G2 phase: arrested
Large-scale survey
null	inviable

Interactions	SFI1 All interactions details and references
	24 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 4 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 5

Sequence Information

ChrXII:143200 to 146040 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2841	143200..146040	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003926

SFI1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SFI1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SFI1]

1)	Ma P, et al. (1999) Deletion of SFI1, a novel suppressor of partial Ras-cAMP pathway deficiency in the yeast Saccharomyces cerevisiae, causes G(2) arrest. Yeast 15(11):1097-109
2)	Kilmartin JV (2003) Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. J Cell Biol 162(7):1211-21

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