DNM1/YLL001W Summary Help

Standard Name DNM1 1
Systematic Name YLL001W
Feature Type ORF, Verified
Description Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance (1, 2, 3, 4, 5)
Name Description DyNaMin-related 1
Chromosomal Location
ChrXII:147890 to 150163 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DNM1 GO evidence and references
  View Computational GO annotations for DNM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
223 total interaction(s) for 107 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 10
  • Co-fractionation: 1
  • Co-localization: 3
  • Co-purification: 1
  • FRET: 2
  • PCA: 6
  • Reconstituted Complex: 3
  • Two-hybrid: 20

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 103
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 13
  • Positive Genetic: 12
  • Synthetic Growth Defect: 7
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 757
Molecular Weight (Da) 84,971
Isoelectric Point (pI) 5.25
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:147890 to 150163 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2274 147890..150163 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003924
References cited on this page View Complete Literature Guide for DNM1
1) Gammie AE, et al.  (1995) DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast. J Cell Biol 130(3):553-66
2) Otsuga D, et al.  (1998) The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast. J Cell Biol 143(2):333-49
3) Bleazard W, et al.  (1999) The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Nat Cell Biol 1(5):298-304
4) Mozdy AD, et al.  (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80
5) Kuravi K, et al.  (2006) Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci 119(Pt 19):3994-4001