Standard Name	PCC1 1
Systematic Name	YKR095W-A
Feature Type	ORF, Verified
Description	Component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription (1, 2, 3)
Name Description	Polarized growth Chromatin-associated Controller 1

Chromosomal Location	ChrXI:625864 to 626205 | ORF Map | GBrowse

	View Computational GO annotations for PCC1
Molecular Function
Manually curated	chromatin DNA binding (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter by pheromones (IMP) threonylcarbamoyladenosine metabolic process (IMP)
Cellular Component
Manually curated	EKC/KEOPS complex (IDA) colocalizes_with nuclear chromatin (IDA)

Classical genetics
conditional	cell cycle progression in G1 phase: arrested cell cycle progression in M phase: arrested heat sensitivity: increased mating projection morphology: absent
null	tRNA-Ile modification: absent heat sensitivity: increased vegetative growth: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	15 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Far Western: 1 Reconstituted Complex: 2
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:625864 to 626205 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2004-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..38 625864..625901 2011-02-03 2004-01-28 Intron 39..113 625902..625976 2011-02-03 2004-01-28 CDS 114..342 625977..626205 2011-02-03 2004-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (39 - 113)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000028512