SRL3/YKR091W Summary Help

Standard Name SRL3 1
Systematic Name YKR091W
Alias WHI7 2
Feature Type ORF, Verified
Description GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog, WHI5, that arose from the whole genome duplication (1, 3, 4, 5, 6)
Name Description Suppressor of rad53 Lethality 1
Chromosomal Location
ChrXI:611525 to 612265 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SRL3 GO evidence and references
  View Computational GO annotations for SRL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
49 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 38
  • Positive Genetic: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 246
Molecular Weight (Da) 27,465
Isoelectric Point (pI) 8.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:611525 to 612265 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2004-07-23
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..741 611525..612265 2011-02-03 2004-07-23
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001799
References cited on this page View Complete Literature Guide for SRL3
1) Desany BA, et al.  (1998) Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev 12(18):2956-70
2) Yahya G, et al.  (2014) A whi7-anchored loop controls the g1 cdk-cyclin complex at start. Mol Cell 53(1):115-26
3) Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Travesa A, et al.  (2013) Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6. Mol Cell Biol 33(8):1476-86