Standard Name	TGL4 1
Systematic Name	YKR089C
Alias	STC1
Feature Type	ORF, Verified
Description	Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication (2, 3, 4, 5, 6)
Name Description	TriacylGlycerol Lipase 1

Chromosomal Location	ChrXI:608365 to 605633 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TGL4
Molecular Function
Manually curated	calcium-independent phospholipase A2 activity (IDA, IMP) lysophosphatidic acid acyltransferase activity (IDA) sterol esterase activity (IDA, IMP) triglyceride lipase activity (IDA, IMP)
Biological Process
Manually curated	cell budding (IGI, IMP) phospholipid metabolic process (IMP) triglyceride catabolic process (IGI, IMP) triglyceride mobilization (IDA, IMP)
Cellular Component
Manually curated	colocalizes_with lipid particle (IDA) lipid particle (IDA)
High-throughput	lipid particle (IDA)

Classical genetics
null	triglyceride accumulation: increased viable
reduction of function	triglyceride accumulation: increased
Large-scale survey
null	competitive fitness: decreased dessication resistance: decreased resistance to benzo[a]pyrene: decreased resistance to nickel sulfate: decreased sporulation: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	45 total interaction(s) for 37 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Biochemical Activity: 1 PCA: 1
Genetic Interactions	Dosage Growth Defect: 2 Negative Genetic: 23 Phenotypic Enhancement: 2 Synthetic Growth Defect: 10 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:608365 to 605633 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2733 608365..605633 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001797