UTH1/YKR042W Summary

UTH1/YKR042W Summary

Standard Name	UTH1
Systematic Name	YKR042W
Feature Type	ORF, Verified
Description	Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8)
Name Description	yoUTH 1, 9

Chromosomal Location	ChrXI:519527 to 520624 \| ORF Map \| GBrowse

Gene Ontology Annotations All UTH1 GO evidence and references

	View Computational GO annotations for UTH1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	fungal-type cell wall biogenesis (IMP) mitochondrion degradation (IMP) negative regulation of chromatin silencing involved in replicative cell aging (TAS)
Cellular Component
Manually curated	fungal-type cell wall (IDA) mitochondrial outer membrane (TAS)

Mutant phenotypes All UTH1 Phenotype evidence and references

Classical genetics
null	chitin deposition: decreased heat sensitivity: decreased metal resistance: decreased mitophagy: decreased oxidative stress resistance: increased replicative lifespan: decreased replicative lifespan: increased resistance to ethanol: increased resistance to zymolyase: increased resistance to sodium dodecyl sulfate: increased resistance to Calcofluor White: increased resistance to mercaptoethanol: increased resistance to sirolimus: increased resistance to paraquat: decreased resistance to tunicamycin: decreased viability: increased
unspecified	replicative lifespan: increased
Large-scale survey
null	polyphosphate accumulation: abnormal chitin deposition: decreased competitive fitness: decreased dessication resistance: decreased hyperosmotic stress resistance: decreased resistance to arsenite(3-): increased resistance to sodium arsenite: increased resistance to elesclomol-Cu: decreased resistance to BPS: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased respiratory growth: decreased rate starvation resistance: decreased stress resistance: decreased toxin resistance: increased viable
Resources	PROPHECY \| SCMD \| ScreenTroll \| Yeast Fitness Database

interactions All UTH1 Interaction evidence and references

	156 total interaction(s) for 95 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 4
Genetic Interactions	Negative Genetic: 97 Phenotypic Enhancement: 18 Phenotypic Suppression: 10 Positive Genetic: 15 Synthetic Growth Defect: 4 Synthetic Lethality: 4 Synthetic Rescue: 2
Resources	BioGRID \| BOND \| BioPIXIE \| CYC2008 (complexes) \| Complexome \| DRYGIN \| GeneMANIA \| InterologFinder

Expression Summary


Resources	Expression Summary \| Cell cycle and metabolic oscillation \| Cell cycle transcript profile \| Cyclebase \| Genevestigator \| GermOnline \| SPELL \| YMGV \| YeastFunc

Protein Information All UTH1 Protein evidence and references

Localization	YeastRC \| YPL+ \| YeastGFP
Phosphorylation	PhosphoGRID \| PhosphoPep Database
Structure	GPMDB \| SCOP
Homologs	Ashbya (AGD) \| Fungal Orthogroups Repository \| P-POD \| PDB Homologs \| PhylomeDB \| YGOB \| YOGY

sequence information

ChrXI:519527 to 520624 | |

SGD ORF map

Last Update

Coordinates: 2011-02-03 | Sequence: 2005-11-03

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1098	519527..520624	2011-02-03	2005-11-03

Retrieve sequences

Analyze Sequence

S288C only	BLASTP \| ATCC/WashU Clones \| BLASTN \| Design Primers \| Restriction Fragment Map \| Restriction Fragment Sizes \| Six-Frame Translation
S288C vs. other species	Fungal Alignment \| BLASTN vs. fungi \| BLASTP at NCBI \| BLASTP vs. fungi \| Synteny Viewer
S288C vs. other strains	Strain Alignment

Resources

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| Search all NCBI (Entrez) \| UniProtKB

Primary SGDID	S000001750

References cited on this page View Complete Literature Guide for UTH1

1)	Kennedy BK, et al. (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80(3):485-96
2)	Bandara PD, et al. (1998) Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response. Curr Genet 34(4):259-68
3)	Camougrand NM, et al. (2000) The "SUN" family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae. Arch Biochem Biophys 375(1):154-60
4)	Velours G, et al. (2002) Dual cell wall/mitochondria localization of the 'SUN' family proteins. FEMS Microbiol Lett 207(2):165-72
5)	Kissova I, et al. (2004) Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 279(37):39068-74
6)	Camougrand N, et al. (2003) The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin. Mol Microbiol 47(2):495-506
7)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
8)	Ritch JJ, et al. (2010) The Saccharomyces SUN gene, UTH1, is involved in cell wall biogenesis. FEMS Yeast Res 10(2):168-76
9)	Austriaco NR Jr (1996) Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. Yeast 12(7):623-30