Systematic Name	YKL222C
Feature Type	ORF, Verified
Description	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine (1, 2)

Chromosomal Location	ChrXI:5620 to 3503 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YKL222C
Molecular Function
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	biological_process unknown (ND)
Cellular Component
Manually curated	mitotic spindle (IDA) nucleus (IDA)
High-throughput	colocalizes_with ribosome (IDA)

Binding motifs	ACGGARWT 3 [Search intergenic regions for ACGGARWT] CGGANAT 4 [Search intergenic regions for CGGANAT]
Resources	ScerTF | UniProbe | YeTFaSCo

Classical genetics
null	resistance to caffeine: decreased viable
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased haploinsufficient hyperosmotic stress resistance: decreased resistance to 4-nitroquinoline N-oxide: normal resistance to cycloheximide: increased resistance to oligomycin: normal resistance to chloramphenicol: normal resistance to ketoconazole: normal resistance to rhodamine 6-G: normal starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	10 total interaction(s) for 10 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1
Genetic Interactions	Negative Genetic: 8 Positive Genetic: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:5620 to 3503 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2118 5620..3503 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001705