MNN4/YKL201C Summary Help

Standard Name MNN4 1
Systematic Name YKL201C
Alias YKL200C 2 , 3
Feature Type ORF, Verified
Description Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication (2, 4, 5, 6)
Name Description MaNNosyltransferase
Chromosomal Location
ChrXI:67466 to 63930 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -132.6 cM
Gene Ontology Annotations All MNN4 GO evidence and references
  View Computational GO annotations for MNN4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
42 total interaction(s) for 34 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 4
  • PCA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 27
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 5

Expression Summary
Length (a.a.) 1,178
Molecular Weight (Da) 139,380
Isoelectric Point (pI) 6.46
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXI:67466 to 63930 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YKL200C
Genetic position: -132.6 cM
Last Update Coordinates: 2011-02-03 | Sequence: 2001-05-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3537 67466..63930 2011-02-03 2001-05-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001684
References cited on this page View Complete Literature Guide for MNN4
1) Raschke WC, et al.  (1973) Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants. J Biol Chem 248(13):4660-6
2) Odani T, et al.  (1996) Cloning and analysis of the MNN4 gene required for phosphorylation of N-linked oligosaccharides in Saccharomyces cerevisiae. Glycobiology 6(8):805-10
3) Cherry JM, et al.  (1998) "Genetic and Physical Maps of Saccharomyces cerevisiae (Edition 15)". Pp. 414-420 in 1998 Yeast Genetics and Molecular Biology Meeting Program and Abstracts. Bethesda, MD: The Genetics Society of America
4) Odani T, et al.  (1997) Mannosylphosphate transfer to cell wall mannan is regulated by the transcriptional level of the MNN4 gene in Saccharomyces cerevisiae. FEBS Lett 420(2-3):186-90
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Carvalho-Netto OV, et al.  (2013) A simple and effective set of PCR-based molecular markers for the monitoring of the Saccharomyces cerevisiae cell population during bioethanol fermentation. J Biotechnol 168(4):701-9