Standard Name	CNB1 1
Systematic Name	YKL190W
Alias	CRV1 , YCN2
Feature Type	ORF, Verified
Description	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress (2, 3, 4)
Name Description	CalciNeurin subunit B

Chromosomal Location	ChrXI:82947 to 83550 | ORF Map | GBrowse

	View Computational GO annotations for CNB1
Molecular Function
Manually curated	calcium ion binding (ISS) contributes_to calcium-dependent protein serine/threonine phosphatase activity (IDA, ISS)
Biological Process
Manually curated	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion (IMP) cellular ion homeostasis (IMP) fungal-type cell wall organization (IGI, IMP)
Cellular Component
Manually curated	calcineurin complex (IDA, IPI)

Classical genetics
null	calcium(2+) accumulation: increased ionic stress resistance: decreased necrotic cell death: decreased replicative lifespan: decreased resistance to Plakortide F acid: decreased resistance to mercaptoethanol: decreased resistance to L-1,4-dithiothreitol: decreased resistance to tunicamycin: decreased resistance to cadmium chloride: decreased
Large-scale survey
null	alkaline pH resistance: decreased auxotrophy chitin deposition: normal competitive fitness: decreased hyperosmotic stress resistance: decreased ionic stress resistance: decreased metal resistance: decreased resistance to tunicamycin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to methyl methanesulfonate: increased resistance to mycophenolic acid: increased resistance to arsenite(3-): decreased resistance to (S)-lactic acid: decreased resistance to hydrogen chloride: decreased resistance to 1,4-dithiothreitol: decreased resistance to cycloheximide: decreased resistance to caffeine: decreased resistance to fenpropimorph: decreased resistance to ciclopirox olamine: decreased resistance to elesclomol-Cu: decreased resistance to lovastatin: decreased resistance to miconazole: decreased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	233 total interaction(s) for 166 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 4 Affinity Capture-Western: 1 PCA: 2 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 15 Negative Genetic: 92 Phenotypic Enhancement: 9 Phenotypic Suppression: 5 Positive Genetic: 5 Synthetic Growth Defect: 19 Synthetic Lethality: 51 Synthetic Rescue: 14
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:82947 to 83550 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..52 82947..82998 2011-02-03 1996-07-31 Intron 53..128 82999..83074 2011-02-03 1996-07-31 CDS 129..604 83075..83550 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (53 - 128)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001673