MCR1/YKL150W Summary Help

Standard Name MCR1 1, 2
Systematic Name YKL150W
Feature Type ORF, Verified
Description Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis (1, 3)
Name Description Mitochondrial NADH-Cytochrome b5 Reductase 1
Chromosomal Location
ChrXI:166544 to 167452 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MCR1 GO evidence and references
  View Computational GO annotations for MCR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 10 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
49 total interaction(s) for 38 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Co-purification: 1
  • PCA: 3
  • Protein-peptide: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 23
  • Positive Genetic: 4
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 302
Molecular Weight (Da) 34,138
Isoelectric Point (pI) 9.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:166544 to 167452 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
5' UTR intron -144..-57 166400..166487 2011-02-03 2007-04-04
CDS 1..909 166544..167452 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001633
References cited on this page View Complete Literature Guide for MCR1
1) Hahne K, et al.  (1994) Incomplete arrest in the outer membrane sorts NADH-cytochrome b5 reductase to two different submitochondrial compartments. Cell 79(5):829-39
2) Vandenbol M and Fairhead C  (2000) Mass-murder deletion of 19 ORFs from Saccharomyces cerevisiae chromosome XI. Gene 247(1-2):45-52
3) Lamb DC, et al.  (1999) Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Lett 462(3):283-8