Standard Name	MCR1 1, 2
Systematic Name	YKL150W
Feature Type	ORF, Verified
Description	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis (1, 3)
Name Description	Mitochondrial NADH-Cytochrome b5 Reductase 1

Chromosomal Location	ChrXI:166544 to 167452 | ORF Map | GBrowse

	View Computational GO annotations for MCR1
Molecular Function
Manually curated	cytochrome-b5 reductase activity, acting on NAD(P)H (IDA)
Biological Process
Manually curated	cellular response to oxidative stress (IMP) ergosterol biosynthetic process (IDA)
Cellular Component
Manually curated	integral to mitochondrial outer membrane (IDA) mitochondrial intermembrane space (IDA) mitochondrial outer membrane (IDA)
High-throughput	mitochondrial outer membrane (IDA) mitochondrion (IDA)

Classical genetics
null	oxidative stress resistance: decreased toxin resistance: increased viable
overexpression	oxidative stress resistance: increased
Large-scale survey
null	UV resistance: decreased competitive fitness: normal haploproficient vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	47 total interaction(s) for 37 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 3 Biochemical Activity: 1 Co-fractionation: 1 PCA: 3 Protein-peptide: 2 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 23 Positive Genetic: 4 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:166544 to 167452 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence 5' UTR intron -144..-57 166400..166487 2011-02-03 2007-04-04 CDS 1..909 166544..167452 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Five_prime_UTR_intron Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001633