Standard Name	CMC1 1
Systematic Name	YKL137W
Feature Type	ORF, Verified
Description	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif (1, 2)
Name Description	Cx9C Mitochondrial protein necessary for full assembly of Cytochrome c oxidase 1

Chromosomal Location	ChrXI:185957 to 186292 | ORF Map | GBrowse

	View Computational GO annotations for CMC1
Molecular Function
Manually curated	copper ion binding (IDA)
Biological Process
Manually curated	mitochondrial respiratory chain complex IV assembly (IGI, IMP)
Cellular Component
Manually curated	extrinsic to mitochondrial inner membrane (IDA) mitochondrial intermembrane space (IDA)

Classical genetics
null	cytochrome c reductase activity: decreased cytochrome c oxidase activity: decreased Cox2p accumulation: decreased respiratory growth: decreased rate
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: normal dessication resistance: decreased respiratory growth: decreased respiratory growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	49 total interaction(s) for 46 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 2 Co-fractionation: 1 Reconstituted Complex: 1
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 35 Phenotypic Enhancement: 1 Positive Genetic: 3 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:185957 to 186292 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2005-12-15
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..336 185957..186292 2011-02-03 2005-12-15
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001620