HSL1/YKL101W Summary Help

Standard Name HSL1
Systematic Name YKL101W
Alias NIK1 , ELM2 1
Feature Type ORF, Verified
Description Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p (2, 3, 4, 5, 6)
Name Description Histone Synthetic Lethal 7
Chromosomal Location
ChrXI:248920 to 253476 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HSL1 GO evidence and references
  View Computational GO annotations for HSL1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant phenotypes All HSL1 Phenotype evidence and references
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
overexpression
Resources
interactions All HSL1 Interaction evidence and references
457 total interaction(s) for 289 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 19
  • Biochemical Activity: 74
  • Co-localization: 1
  • PCA: 9
  • Protein-peptide: 1
  • Reconstituted Complex: 17
  • Two-hybrid: 11
Genetic Interactions
  • Dosage Growth Defect: 27
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 198
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 5
  • Positive Genetic: 25
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 20
  • Synthetic Rescue: 14
Resources
Expression Summary
histogram
Resources
Protein Information All HSL1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:248920 to 253476 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4557 248920..253476 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001584
References cited on this page View Complete Literature Guide for HSL1
1) Thomas CL, et al.  (2003) Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Yeast 20(9):813-26
2) McMillan JN, et al.  (1999) The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol 19(10):6929-39
3) Shulewitz MJ, et al.  (1999) Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7123-37
4) Longtine MS, et al.  (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61
5) Barral Y, et al.  (1999) Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast. Genes Dev 13(2):176-87
6) Sakchaisri K, et al.  (2004) Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A 101(12):4124-9
7) Ma XJ, et al.  (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40