CUE2/YKL090W Summary Help

Standard Name CUE2 1
Systematic Name YKL090W
Feature Type ORF, Verified
Description Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination (1)
Name Description Coupling of Ubiquitin conjugation to ER degradation 2
Chromosomal Location
ChrXI:271878 to 273209 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CUE2 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
Resources
13 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Co-crystal Structure: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 2
  • Positive Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 443
Molecular Weight (Da) 50,873
Isoelectric Point (pI) 7.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:271878 to 273209 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1332 271878..273209 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001573
References cited on this page View Complete Literature Guide for CUE2
1) Shih SC, et al.  (2003) A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J 22(6):1273-81
2) Biederer T, et al.  (1997) Role of Cue1p in ubiquitination and degradation at the ER surface. Science 278(5344):1806-9