SMY1/YKL079W Summary Help

Standard Name SMY1 1
Systematic Name YKL079W
Feature Type ORF, Verified
Description Kinesin-like myosin passenger-protein; interacts with Myo2p; controls actin cable structure and dynamics; proposed to be involved in exocytosis (2, 3, 4)
Name Description Suppressor of MYo2-66 1
Chromosomal Location
ChrXI:286603 to 288573 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SMY1 GO evidence and references
  View Computational GO annotations for SMY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
repressible
Resources
219 total interaction(s) for 153 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 6
  • FRET: 2
  • PCA: 3
  • Reconstituted Complex: 2
  • Two-hybrid: 124

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Rescue: 5
  • Negative Genetic: 35
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 12
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 656
Molecular Weight (Da) 73,799
Isoelectric Point (pI) 6.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:286603 to 288573 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1971 286603..288573 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001562
References cited on this page View Complete Literature Guide for SMY1
1) Lillie SH and Brown SS  (1992) Suppression of a myosin defect by a kinesin-related gene. Nature 356(6367):358-61
2) Beningo KA, et al.  (2000) The yeast kinesin-related protein Smy1p exerts its effects on the class V myosin Myo2p via a physical interaction. Mol Biol Cell 11(2):691-702
3) Lillie SH and Brown SS  (1998) Smy1p, a kinesin-related protein that does not require microtubules. J Cell Biol 140(4):873-83
4) Chesarone-Cataldo M, et al.  (2011) The Myosin passenger protein smy1 controls actin cable structure and dynamics by acting as a formin damper. Dev Cell 21(2):217-30