MDM35/YKL053C-A Summary Help

Standard Name MDM35 1
Systematic Name YKL053C-A
Feature Type ORF, Verified
Description Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description Mitochondrial Distribution and Morphology 1
Chromosomal Location
ChrXI:339442 to 339182 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MDM35 GO evidence and references
  View Computational GO annotations for MDM35
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
243 total interaction(s) for 186 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 5
  • Co-fractionation: 3
  • Co-purification: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 163
  • Phenotypic Suppression: 1
  • Positive Genetic: 50
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 86
Molecular Weight (Da) 9,712
Isoelectric Point (pI) 4.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:339442 to 339182 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..261 339442..339182 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007243
References cited on this page View Complete Literature Guide for MDM35
1) Dimmer KS, et al.  (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
2) Gabriel K, et al.  (2007) Novel Mitochondrial Intermembrane Space Proteins as Substrates of the MIA Import Pathway. J Mol Biol 365(3):612-620
3) Longen S, et al.  (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76