ELM1/YKL048C Summary Help

Standard Name ELM1
Systematic Name YKL048C
Alias LDB9
Feature Type ORF, Verified
Description Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring (1, 2, 3, 4, 5 and see Summary Paragraph)
Name Description ELongated Morphology 6
Chromosomal Location
ChrXI:349136 to 347214 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ELM1 GO evidence and references
  View Computational GO annotations for ELM1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle (365, 293, 281)
Mutant phenotypes All ELM1 Phenotype evidence and references
Classical genetics
null
overexpression
Large-scale survey
null
Resources
interactions All ELM1 Interaction evidence and references
593 total interaction(s) for 423 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-Western: 2
  • Biochemical Activity: 14
  • Co-localization: 1
  • PCA: 2
  • Reconstituted Complex: 10
Genetic Interactions
  • Dosage Growth Defect: 92
  • Dosage Lethality: 2
  • Dosage Rescue: 3
  • Negative Genetic: 304
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 4
  • Positive Genetic: 53
  • Synthetic Growth Defect: 51
  • Synthetic Lethality: 29
  • Synthetic Rescue: 12
Resources
Expression Summary
histogram
Resources
Protein Information All ELM1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:349136 to 347214 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1923 349136..347214 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001531
SUMMARY PARAGRAPH for ELM1

Elm1p is a serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis (2, 4, 1). Elm1p is required for the normal hyperphosphorylation of the Swe1p kinase during mitosis, and for the proper regulation of a number of other kinases, including Snf1p, Cla4p, and Gin4p (3). Elm1p interacts genetically with Cla4p, Gin4p, and the mitotic cyclins (3).

Elm1p is localized at the bud neck in a septin-dependent fashion from bud emergence until the completion of anaphase, at about the time of cell division (1). Elm1p forms part of the bud neck ring, and is required for the localization of Hsl1p and Cdc12p to the bud neck ring (5).

Strains mutant in Elm1p display ectopic localization of Cdc12p at the bud tip (5), delayed cytokinesis (1), failure to negatively regulate polar bud growth during mitosis, and defects in septin organization (3). Deletion results in constitutive filamentous growth (7); overexpression causes elongated bud formation (8).

Last updated: 2004-04-15

References cited on this page View Complete Literature Guide for ELM1
1) Bouquin N, et al.  (2000) Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae. J Cell Sci 113 ( Pt 8)():1435-45
2) Garrett JM  (1997) The control of morphogenesis in Saccharomyces cerevisiae by Elm1 kinase is responsive to RAS/cAMP pathway activity and tryptophan availability. Mol Microbiol 26(4):809-20
3) Sreenivasan A and Kellogg D  (1999) The elm1 kinase functions in a mitotic signaling network in budding yeast. Mol Cell Biol 19(12):7983-94
4) Koehler CM and Myers AM  (1997) Serine-threonine protein kinase activity of Elm1p, a regulator of morphologic differentiation in Saccharomyces cerevisiae. FEBS Lett 408(1):109-14
5) Thomas CL, et al.  (2003) Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Yeast 20(9):813-26
6) Blacketer MJ, et al.  (1993) Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A. Mol Cell Biol 13(9):5567-81
7) Edgington NP, et al.  (1999) Control of Saccharomyces cerevisiae filamentous growth by cyclin-dependent kinase Cdc28. Mol Cell Biol 19(2):1369-80
8) Moriya H and Isono K  (1999) Analysis of genetic interactions between DHH1, SSD1 and ELM1 indicates their involvement in cellular morphology determination in Saccharomyces cerevisiae. Yeast 15(6):481-96