PHD1/YKL043W Summary

PHD1 BASIC INFORMATION

Standard Name	PHD1 1
Systematic Name	YKL043W
Feature Type	ORF, Verified
Description	Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate (1, 2, 3)
Name Description	PseudoHyphal Determinant 1

GO Annotations	All PHD1 GO evidence and references
	View Computational GO annotations for PHD1
Molecular Function
Manually curated	transcription factor activity (IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IMP, ISS) pseudohyphal growth (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Regulatory Role
Binding motifs	PHD1 Transcription Factor Binding Sites and References
	SCNGCNGG

Mutant Phenotype	All PHD1 Phenotype details and references
Classical genetics
null	pseudohyphal growth: decreased
overexpression	pseudohyphal growth: increased
Large-scale survey
null	filamentous growth: decreased invasive growth: absent replicative lifespan: increased transposable element transposition: increased viable
overexpression	filamentous growth: increased

Interactions	PHD1 All interactions details and references
	13 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Biochemical Activity: 2 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 5 Phenotypic Enhancement: 1 Synthetic Growth Defect: 1

Sequence Information

ChrXI:356392 to 357492 | |

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1101	356392..357492	2005-12-15	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001526

PHD1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PHD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PHD1]

1)	Gimeno CJ and Fink GR (1994) Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development. Mol Cell Biol 14(3):2100-12
2)	Pan X and Heitman J (2000) Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Mol Cell Biol 20(22):8364-72
3)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64

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