Standard Name	PHD1 1
Systematic Name	YKL043W
Feature Type	ORF, Verified
Description	Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	PseudoHyphal Determinant 1

Chromosomal Location	ChrXI:356748 to 357848 | ORF Map | GBrowse

	View Computational GO annotations for PHD1
Molecular Function
Manually curated	sequence-specific DNA binding transcription factor activity (IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	positive regulation of transcription from RNA polymerase II promoter (IMP, ISS) pseudohyphal growth (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Binding motifs	Predicted PHD1 Binding Site Locations
	CNTGCAT 6 [Search intergenic regions for CNTGCAT] SCNGCNGG 7 [Search intergenic regions for SCNGCNGG] SMTGCAB 8 [Search intergenic regions for SMTGCAB]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	pseudohyphal growth: decreased
overexpression	pseudohyphal growth: increased
Large-scale survey
null	competitive fitness: normal filamentous growth: decreased invasive growth: absent replicative lifespan: increased resistance to benzo[a]pyrene: decreased transposable element transposition: increased viable
overexpression	filamentous growth: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	41 total interaction(s) for 38 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 2 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 2 Dosage Rescue: 6 Negative Genetic: 14 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 6 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:356748 to 357848 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1101 356748..357848 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001526