Standard Name	MRT4
Systematic Name	YKL009W
Feature Type	ORF, Verified
Description	Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus (1, 2, 3)
Name Description	mRNA Turnover 4 1

Chromosomal Location	ChrXI:426242 to 426952 | ORF Map | GBrowse

	View Computational GO annotations for MRT4
Molecular Function
Manually curated	LSU rRNA binding (ISA)
Biological Process
Manually curated	nuclear-transcribed mRNA catabolic process (IMP) ribosomal large subunit assembly (IGI, IMP) ribosomal large subunit biogenesis (IMP, IPI) rRNA processing (IMP)
Cellular Component
Manually curated	nucleolus (IDA) nucleoplasm (IDA) colocalizes_with preribosome, large subunit precursor (IDA) preribosome, large subunit precursor (IDA)
High-throughput	nucleolus (IDA) nucleus (IDA) preribosome, large subunit precursor (IDA)

Classical genetics
conditional	STE2 accumulation: increased
null	mature 25S rRNA accumulation: delayed tellurium atom accumulation: increased 60S ribosomal subunit accumulation: decreased Rpl25p-GFP distribution: abnormal resistance to tellurite: decreased vegetative growth: decreased rate viable
Large-scale survey
null	budding index: decreased cell cycle progression in G1 phase: increased duration cell size: decreased chronological lifespan: decreased competitive fitness: decreased fermentative growth: decreased rate haploinsufficient metal resistance: decreased resistance to cycloheximide: decreased resistance to bleomycin: increased resistance to cycloheximide: increased resistance to fluconazole: increased resistance to arsenite(3-): decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to streptomycin: decreased resistance to sorbate: decreased resistance to doxorubicin: decreased stress resistance: increased telomere length: decreased vacuolar morphology: abnormal viable
overexpression	cell cycle progression: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	314 total interaction(s) for 224 unique genes/features.
Physical Interactions	Affinity Capture-MS: 86 Affinity Capture-RNA: 3 Affinity Capture-Western: 98 Co-fractionation: 2
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 62 Phenotypic Enhancement: 1 Positive Genetic: 50 Synthetic Growth Defect: 5 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:426242 to 426952 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..711 426242..426952 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001492