Standard Name	MET14 1
Systematic Name	YKL001C
Feature Type	ORF, Verified
Description	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism (2)
Name Description	METhionine requiring 1

Chromosomal Location	ChrXI:439385 to 438777 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: .8 cM

	View Computational GO annotations for MET14
Molecular Function
Manually curated	adenylylsulfate kinase activity (IDA, IMP)
Biological Process
Manually curated	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) (IMP) sulfur amino acid metabolic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	sulfate assimilation pathway superpathway of sulfur amino acid biosynthesis

Classical genetics
null	auxotrophy tellurium atom accumulation: decreased resistance to tellurite: increased
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased haploinsufficient resistance to cycloheximide: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to nickel(2+): decreased resistance to amiodarone: decreased resistance to nickel sulfate: decreased resistance to paromomycin: decreased utilization of nitrogen source: absent vegetative growth: decreased rate viable
overexpression	filamentous growth: increased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	51 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 Two-hybrid: 4
Genetic Interactions	Negative Genetic: 33 Phenotypic Enhancement: 1 Positive Genetic: 5 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:439385 to 438777 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: .8 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..609 439385..438777 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001484