Standard Name	YKE2 1
Systematic Name	YLR200W
Alias	GIM1 , PFD6
Feature Type	ORF, Verified
Description	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin (2, 3)
Name Description	Yeast ortholog of mouse KE2 1

Chromosomal Location	ChrXII:549012 to 549356 | ORF Map | GBrowse

	View Computational GO annotations for YKE2
Molecular Function
Manually curated	tubulin binding (IDA)
Biological Process
Manually curated	protein folding (IMP, ISS) tubulin complex assembly (IMP, ISS)
Cellular Component
Manually curated	cytoplasm (IDA) prefoldin complex (IPI, ISS)

Classical genetics
null	cell cycle progression: abnormal cell size: increased chromosome/plasmid maintenance: abnormal cold sensitivity: increased metal resistance: decreased resistance to benomyl: decreased vegetative growth: decreased rate viable
Large-scale survey
null	bud morphology: abnormal budding pattern: abnormal cell shape: abnormal cell size: increased competitive fitness: decreased endocytosis: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to benomyl: decreased resistance to cycloheximide: decreased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to sirolimus: decreased resistance to amiodarone: decreased resistance to hydroxyurea: decreased resistance to ethanol: decreased resistance to dihydromotuporamine C: decreased resistance to arsenite(3-): decreased resistance to sodium arsenite: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to wortmannin: normal resistance to propan-1-ol: decreased resistance to benzo[a]pyrene: decreased stress resistance: increased transposable element transposition: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	915 total interaction(s) for 464 unique genes/features.
Physical Interactions	Affinity Capture-MS: 28 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 PCA: 6 Two-hybrid: 37
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 2 Negative Genetic: 387 Phenotypic Enhancement: 9 Phenotypic Suppression: 7 Positive Genetic: 164 Synthetic Growth Defect: 168 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 89 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:549012 to 549356 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..345 549012..549356 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004190