YJR142W Summary Help

Systematic Name YJR142W
Feature Type ORF, Verified
Description 8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition (1, 2, 3, 4, 5)
Chromosomal Location
ChrX:697141 to 698169 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YJR142W GO evidence and references
  View Computational GO annotations for YJR142W
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
21 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 5

Genetic Interactions
  • Negative Genetic: 7
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 342
Molecular Weight (Da) 39,690
Isoelectric Point (pI) 5.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:697141 to 698169 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1029 697141..698169 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003903
References cited on this page View Complete Literature Guide for YJR142W
1) Huang D, et al.  (2002) Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Mol Cell Biol 22(14):5076-88
2) Mah AS, et al.  (2005) Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem 6():22
3) Nyswaner KM, et al.  (2008) Chromatin-associated genes protect the yeast genome from ty1 insertional mutagenesis. Genetics 178(1):197-214
4) Song MG, et al.  (2013) Multiple Nudix family proteins possess mRNA decapping activity. RNA 19(3):390-9
5) Goyer A, et al.  (2013) A cross-kingdom Nudix enzyme that pre-empts damage in thiamin metabolism. Biochem J 454(3):533-42