EAF6/YJR082C Summary Help

Standard Name EAF6 1
Systematic Name YJR082C
Feature Type ORF, Verified
Description Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 (1, 2)
Name Description Esa1p-Associated Factor 1
Chromosomal Location
ChrX:582255 to 581914 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All EAF6 GO evidence and references
  View Computational GO annotations for EAF6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
overexpression
unspecified
Resources
202 total interaction(s) for 146 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Reconstituted Complex: 11
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Growth Defect: 18
  • Negative Genetic: 54
  • Phenotypic Enhancement: 1
  • Positive Genetic: 16
  • Synthetic Growth Defect: 46
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 113
Molecular Weight (Da) 12,895
Isoelectric Point (pI) 6.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:582255 to 581914 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..342 582255..581914 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003842
References cited on this page View Complete Literature Guide for EAF6
1) Nourani A, et al.  (2001) Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol 21(22):7629-40
2) Taverna SD, et al.  (2006) Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 24(5):785-96