Standard Name	TAH11 1
Systematic Name	YJR046W
Alias	SID2 2 , CDT1 3
Feature Type	ORF, Verified
Description	DNA replication licensing factor, required for pre-replication complex assembly (1, 3)
Name Description	Topo-A Hypersensitive 1

Chromosomal Location	ChrX:522048 to 523862 | ORF Map | GBrowse

	View Computational GO annotations for TAH11
Molecular Function
Manually curated	NOT ATP binding (IDA) NOT DNA replication origin binding (IDA) DNA replication origin binding (IDA)
Biological Process
Manually curated	double-strand break repair via break-induced replication (IMP) nuclear pre-replicative complex assembly (IDA) regulation of DNA-dependent DNA replication initiation (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pre-replicative complex (IDA, IMP) nucleus (IDA)

Classical genetics
null	inviable sporulation efficiency: normal vegetative growth: normal
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	inviable
reduction of function	competitive fitness: normal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	68 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 23 Co-purification: 1 Reconstituted Complex: 16 Two-hybrid: 17
Genetic Interactions	Synthetic Lethality: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:522048 to 523862 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1815 522048..523862 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003807