Standard Name	ESS1 1
Systematic Name	YJR017C
Alias	PTF1 2 , PIN1
Feature Type	ORF, Verified
Description	Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3 (3, 4, 5)
Name Description	ESSential

Chromosomal Location	ChrX:467033 to 466521 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 17 cM

	View Computational GO annotations for ESS1
Molecular Function
Manually curated	peptidyl-prolyl cis-trans isomerase activity (IDA, IMP) RNA polymerase II core binding (IPI)
Biological Process
Manually curated	negative regulation of histone deacetylation (IMP, IPI) negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (IMP) negative regulation of transcription from RNA polymerase II promoter (IGI, IMP) positive regulation of chromatin silencing at rDNA (IMP) positive regulation of protein dephosphorylation (IDA, IMP) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly (IGI) positive regulation of transcription from RNA polymerase II promoter (IGI, IPI) protein peptidyl-prolyl isomerization (IDA, IMP) regulation of transcription involved in G1 phase of mitotic cell cycle (IMP) regulation of transcription involved in G2/M-phase of mitotic cell cycle (IMP) termination of RNA polymerase II transcription (IGI, IMP)
Cellular Component
Manually curated	nucleus (IC)

Classical genetics
conditional	UV resistance: decreased auxotrophy cell cycle progression: arrested heat sensitivity: increased resistance to 4-nitroquinoline-1-oxide: decreased resistance to methyl methanesulfonate: decreased vegetative growth: decreased
null	inviable resistance to cyclosporin A: decreased resistance to tacrolimus (anhydrous): increased vegetative growth: decreased rate
overexpression	vegetative growth: decreased
repressible	cell cycle progression in M phase: arrested
Large-scale survey
null	inviable resistance to clioquinol: decreased
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	161 total interaction(s) for 121 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-RNA: 3 Affinity Capture-Western: 4 Biochemical Activity: 1 Far Western: 1 PCA: 2 Protein-peptide: 63 Reconstituted Complex: 3 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 3 Dosage Rescue: 20 Negative Genetic: 1 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 10 Synthetic Lethality: 11 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:467033 to 466521 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 17 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..513 467033..466521 2011-02-03 2003-09-22
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003778